THE RELATIONSHIP OF SULFAPYRIDINE, NICOTINIC ACID, AND COENZYMES TO THE GROWTH OF STAPHYLOCOCCUS AUREUS

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Article| July 01 1940

Randolph West,

Randolph West

From the Department of Medicine of the Presbyterian Hospital and the College of Physicians and Surgeons, Columbia University, New York

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PubMed

Alvin F. Coburn

From the Department of Medicine of the Presbyterian Hospital and the College of Physicians and Surgeons, Columbia University, New York

Search for other works by this author on:

PubMed

Randolph West

From the Department of Medicine of the Presbyterian Hospital and the College of Physicians and Surgeons, Columbia University, New York

Alvin F. Coburn

From the Department of Medicine of the Presbyterian Hospital and the College of Physicians and Surgeons, Columbia University, New York

Received: May 02 1940

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1940, by The Rockefeller Institute for Medical Research New York

1940

J Exp Med (1940) 72 (1): 91–97.

https://doi.org/10.1084/jem.72.1.91

Our studies indicate that sulfapyridine modifies the normal metabolism of a bacterium.

Coenzymes inhibit the effect of sulfapyridine on the growth of staphylococcus in Knight's medium.

Nicotinic acid does not interfere with the action of sulfapyridine under the same conditions.

The possible relation of sulfapyridine, nicotinic acid, and coenzymes in relation to bacterial growth is discussed.

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Copyright, 1940, by The Rockefeller Institute for Medical Research New York

1940

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