Destruction of large amounts of red cells in normal and bile fistula dogs by means of acetyl phenylhydrazine causes no significant alterations of the blood plasma but there is some decrease in the bile cholesterol.

During Bartonella canis infection the splenectomized bile fistula dog periodically breaks down large quantities of red cells with slight decrease in the plasma cholesterol and marked decrease in the bile cholesterol.

In the periods of blood regeneration following such acute anemias there are no significant alterations in the values for plasma or bile cholesterol.

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