From the results of the experiments described in this paper it is obvious that large amounts of elementary bodies of myxoma can be obtained in a relatively pure state by means of the methods used. Furthermore, it is evident that infectious myxomatosis is a viral disease in which elementary bodies of the same order of magnitude as vaccinal elementary bodies play a conspicuous rô1e in that they either represent the etiological agent or are intimately associated with it. The bodies are specifically agglutinated by antimyxoma serum and are agglutinated to a less extent by serum from rabbits convalescing from fibroma, a disease closely related to myxoma. In virus-free filtrates of emulsions prepared from infected skin there is a soluble precipitinogen or precipitinogens specific for the malady. Moreover, a specific precipitinogen or precipitinogens are demonstrable in virus-free serum of animals acutely ill as a result of extensive infection with myxoma virus. It is believed that this is the second viral disease, yellow fever (14) being the first, in which a specific soluble antigen free from virus has been found in the serum of ill animals.
INFECTIOUS MYXOMATOSIS OF RABBITS : PREPARATION OF ELEMENTARY BODIES AND STUDIES OF SEROLOGICALLY ACTIVE MATERIALS ASSOCIATED WITH THE DISEASE
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Thomas M. Rivers, S. M. Ward; INFECTIOUS MYXOMATOSIS OF RABBITS : PREPARATION OF ELEMENTARY BODIES AND STUDIES OF SEROLOGICALLY ACTIVE MATERIALS ASSOCIATED WITH THE DISEASE . J Exp Med 1 July 1937; 66 (1): 1–14. doi: https://doi.org/10.1084/jem.66.1.1
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