The effect of the administration of suprarenal cortical hormone upon the excretion of sodium and potassium has been studied on normal dogs. It is shown to be qualitatively similar to the effect of this hormone upon suprarenalectomized animals and upon patients with Addison's disease. The phenomenon is proposed as the basis for a suitable method for comparative assay of suprarenal cortical extracts. The method is simple, time saving, and uses a minimum of extract.

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