The increased gonadotropic effect obtained by combining prolan with hypophyseal extracts can be secured equally well by the use of preparations which contain high amounts of the growth or of the gonad-stimulating hormone.

In hypophyseal extracts containing the growth hormone, the synergistic effects do not parallel the content of growth-promoting substance.

Similarly, in hypophyseal extracts containing the gonad-stimulating hormone, the synergistic effects do not parallel the content in the gonadotropic factor.

The hypophyseal substance involved has been prepared sufficiently free of the growth and gonad-stimulating hormones to make it inadmissible to consider either of these substances as responsible for the reaction.

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