The injection of small amounts (1 cc.) of horse serum into the lungs of normal rabbits produces a transient pneumonitis confined to the dorsal aspect of both lungs.

The injection of the same amount of horse serum into the lungs of rabbits that have been previously sensitized to the same serum causes in a high percentage of cases a lesion which is confined to one lung with the gross and microscopic features of lobar (fibrinous) pneumonia as seen in man.

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