The most satisfactory method thus far found for the induction and maintenance of a high degree of hypersensitiveness—"allergy," "hyperergy"—against non-hemolytic streptococci consists in the repeated production of small focal lesions with minimal doses of bacteria.

After a preliminary sensitizing period of about 2 weeks' duration with either large initial, or small multiple daily inoculations, the later foci need be produced only at 7 to 10 day intervals.

Chronicity of low-grade infection appears to be an important factor in the attainment of a high degree of hypersensitiveness.

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