Rabbits bearing very intensive skin lesions resulting from the intracutaneous injection of neurovirus plus testicular extract show typical histological alterations in the gonads, suprarenals, liver, spleen, lung, lymph nodes, and bone marrow.

Similar but less wide-spread alterations are found after intravenous injection of neurovirus.

Although testicle extract injected intracutaneously with neurovirus has a marked enhancing action upon the activity of the latter, the same mixture injected intravenously yields no sign of any such enhancement.

The significance of these observations as regards the question of the ectodermotropism of vaccine virus is discussed, and the doctrine of specific organ affinities is considered.

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