1. In the case investigated, one of Malta fever, the leucocytes were reduced to between 1500 and 3000 per cubic millimetre.

2. Notwithstanding this, the alloxur bodies and the phosphoric acid in the urine, the patient being on an alloxur-free diet, showed no distinct diminution from the normal.

3. The suggestion is made that this result may be due to the leucopenia being brought about by an increased destruction of leucocytes in the spleen rather than to a diminished activity of the bone-marrow.

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