The effect of subcutaneous injections of varying amounts of epinephrine on the hemolysin formation of normal adult albino rats was studied. In one group of experiments the rats received 0.4 mg. per kilo per day in two injections during 3 days prior and 4 days subsequent to the injection of sheep cells. Another series received the same daily amounts but only during 4 days subsequent to the injection of antigen. A third series received the same daily amounts only during 1 day prior and 2 days subsequent to the injection of sheep cells. In a second group of experiments smaller amounts of epinephrine were given during 3 days prior and 4 days subsequent to the injection of antigen. The amounts used were 1/5th, 1/20th, 1/40th, and 1/60th the daily quantity of epinephrine injected in the first group of experiments.

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