The anaphylactic reactions of two non-type-specific fractions of hemolytic streptococcus extracts parallel the precipitin reactions. The nucleoprotein, P, is a true antigen, in that it stimulates antibody production in rabbits, as shown before, and produces anaphylactic shock in guinea pigs actively as well as passively. The probable carbohydrate, C, on the other hand, does not induce antibody formation in rabbits, so far as known at present, but does produce typical anaphylactic shock in guinea pigs passively sensitized with antibacterial serum provided the serum shows a high titer of C precipitins. This is an instance of a hapten, probably carbohydrate in nature, causing anaphylactic shock in passively sensitized guinea pigs.
Article| June 01 1928
THE ANTIGENIC COMPLEX OF STREPTOCOCCUS HÆMOLYTICUS : IV. ANAPHYLAXIS WITH TWO NON-TYPE-SPECIFIC FRACTIONS.
Rebecca C. Lancefield
From the Hospital of The Rockefeller Institute for Medical Research.
Received: March 14 1928
Online Issn: 1540-9538
Print Issn: 0022-1007
Copyright, 1928, by The Rockefeller Institute for Medical Research New York
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Rebecca C. Lancefield; THE ANTIGENIC COMPLEX OF STREPTOCOCCUS HÆMOLYTICUS : IV. ANAPHYLAXIS WITH TWO NON-TYPE-SPECIFIC FRACTIONS. . J Exp Med 1 June 1928; 47 (6): 843–855. doi: https://doi.org/10.1084/jem.47.6.843
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