As the result of these modifications, many of which in themselves may appear trifling, the course of events in the extracorporeal loop is greatly affected. White thrombi, it is true, are laid down in from 10 to 20 minutes, but the formation of fibrin sufficient to cause obstruction is prevented for 3 hours or more. Thus, the observations in normal animals tend to approach those described in Paper III, after the use of anticoagulants such as heparin and hirudine. The new technic offers certain advantages in the study of the details of the early stages of thrombosis.

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