The observations reported in this paper seem to justify the hope that the obstacle afforded to experimentation by the frequent presence of spontaneous encephalitis and nephritis in American and European rabbits does not exist to the same degree in rabbits from certain other localities. The observations are, furthermore despite their obvious limitations, in conformity with the theory that the disease is not one common to domestic rabbits everywhere, but rather that it occurs in special localities from which, given favorable conditions, it may spread. Thus far it has not been reported in tropical climates or south of the equator.

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