1. If due allowance is made for the slow rate of elaboration of cerebrospinal fluid and for the time that it takes for newly formed fluid to emerge from a needle in the cistema, the amount of sugar, chloride, and non-protein nitrogen in the fluid seems to follow in a general way their concentrations in the blood stream.

2. It is equally evident, however, that for any substance other factors besides its concentration in the blood stream play a part in its distribution between blood and cerebrospinal fluid.

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