Chemical changes are reported occurring in the blood of animals with obstruction of the jejunum, in which distilled water or sodium chloride solutions were introduced directly into the lumen of the intestine below the point of obstruction.

Distilled water given daily from the beginning of the obstruction, had no influence on the development or course of the toxemia.

1 and 2 per cent salt solutions prevented a toxemia in uncomplicated cases. One animal so treated lived 30 days.

Distilled water, given after the onset of toxemia, did not alter the progress or outcome of the toxemia.

10 per cent sodium chloride solution, administered after the onset of toxemia, controlled it in most cases for a long period.

Hydrochloric acid had no effect on the course of the toxemia.

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