The skin of guinea pigs in which the virus of typhus fever is propagated, when mildly irritated in advance of the febrile reaction, shows a characteristic exanthem during the height of the experimental disease. More drastic methods of irritation, however, cause a dermatitis which obscures the rash but produce in the corium more marked specific histopathological changes. The exanthem may aid the study of the specific incitant of typhus fever in the lesions.

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