By passage through a series of eleven rabbits a culture of the hogcholera bacillus has increased its virulence a thousand times. A subcutaneous injection of twenty organisms, or 0.00000001 cc. of a 24 hour bouillon culture, or a drop of a bouillon culture rubbed lightly into the shaven skin, produces, in the rabbit, a characteristic disease resulting in death on or about the 6th day.
Article| September 01 1917
INCREASED VIRULENCE OF THE HOG-CHOLERA BACILLUS PRODUCED BY PASSAGE THROUGH RABBITS
From the Department of Animal Pathology of The Rockefeller Institute for Medical Research, Princeton, N. J.
Received: May 18 1917
Online Issn: 1540-9538
Print Issn: 0022-1007
Copyright, 1917, by The Rockefeller Institute for Medical Research New York
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Carl Tenbroeck; INCREASED VIRULENCE OF THE HOG-CHOLERA BACILLUS PRODUCED BY PASSAGE THROUGH RABBITS . J Exp Med 1 September 1917; 26 (3): 437–440. doi: https://doi.org/10.1084/jem.26.3.437
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