In as far as the observations reported have a bearing on the movements of fluid within the eye, they are, for the most part, in accord with views at present generally accepted. On the other hand, we know of no other way in which it may be so readily demonstrated that simple and even temporary local circulatory changes may profoundly alter the distribution of substances from the circulating blood to the extravascular fluids and tissues. In the light of these observations, it would seem that such changes might easily account for marked idiosyncrasies in the action of poisonous drugs, and as well probably for other factors in drug action.

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