Since its inception in 1896, Journal of Experimental Medicine (JEM) has been a leader in publishing outstanding and enduring studies in medical biology and has greatly contributed to the fields of immunology, cancer biology, vascular biology, microbial pathogenesis, neuroscience, and stem cell biology. It was conceived 125 yr ago in the pursuit of presenting different areas of medical investigation together so that readers could identify common threads in their methods, problems, and purposes. Today, as other publishers establish topic-specific journals, JEM remains faithful to its broad scope and continues to offer a distinguished venue for the publication of studies that integrate disciplines within the field of disease pathogenesis.

We are thrilled to celebrate this incredible milestone with anniversary content throughout the year, some of which will be published in our regular issues, and all of which will be curated in our anniversary home page (bit.ly/jem125th). Readers will learn from award-winning JEM authors whose contributions have dramatically changed the immunology field or given rise to new fields of research, see how methods and techniques have evolved since the journal’s founding, and read personal stories from like-minded researchers who built their careers starting with a JEM study. As we look back at scientific achievements made over the past 125 yr, we will also be announcing new initiatives that contribute to the future of the fields covered in JEM.

We are extremely grateful to our editors and reviewers, who have contributed to the strength of JEM’s purpose, to our authors for submitting their best research to JEM, and to you, our readers, for your continuous interest in JEM. We hope you will join us during this exceptional year of celebrations and help us commemorate JEM’s 125th anniversary. Throughout the year, we encourage your feedback on Twitter with the hashtag #JEM125 and our handle @JExpMed (twitter.com/JExpMed) or by emailing us at jem@rockefeller.edu. We also encourage you to sign up for special collections and announcements here: bit.ly/jem-sign-up.

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