Muraro et al., reporting on page 805, use stem cell transplants to suppress active multiple sclerosis (MS), and then show that the treatment increased the number of naive T cells at the expense of the memory T cells that are associated with disease.
Muraro and colleagues now provide the first evidence that stem cell transplantation allows patients to regenerate a new repertoire of T cells that are less activated and more diverse than their pretransplant repertoires. This suggests that many of the disease-causing T cells—most of which have a memory phenotype—were eliminated by the treatment.
However, concrete proof that autoreactive T cells are reduced or eliminated is difficult to obtain, partly because the specificities of the autoreactive T cells that invade the central nervous system are not well defined.
The difficulty in assessing the basis for treatment success is one problem. Another is the possibility that autoreactive cells will reemerge from the pool of transferred stem cells. The authors agree that these cells could eventually come back, but hope that resetting the immune system may improve the quality of life for patients with an otherwise poor prognosis.
They emphasize, however, that this intense therapy is probably only suited to a subset of MS patients who have active and aggressive disease and that its implementation will require careful patient selection.