Epstein-Barr Virus Nuclear Antigen 1 from Immunologically Invisible to a Promising T Cell Target

Münz , Christian

doi:10.1084/jem.20040730

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Commentary| May 17 2004

Epstein-Barr Virus Nuclear Antigen 1 : from Immunologically Invisible to a Promising T Cell Target

Christian Münz

Laboratory of Viral Immunobiology, and Christopher H. Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021

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Author and Article Information

Christian Münz

Laboratory of Viral Immunobiology, and Christopher H. Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021

Address correspondence to Christian Münz, Laboratory of Viral Immunobiology, The Rockefeller University, 1230 York Ave., New York, NY 10021. Phone: (212) 327-7611; Fax: (212) 327-7887; email: [email protected]

Received: April 13 2004

Accepted: April 19 2004

Online ISSN: 1540-9538

Print ISSN: 0022-1007

The Rockefeller University Press

2004

J Exp Med (2004) 199 (10): 1301–1304.

https://doi.org/10.1084/jem.20040730

Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1)—the one EBV antigen that is expressed in all EBV-associated malignancies—has long been thought to go undetected by the cell-mediated immune system. However, recent studies show that EBNA1 can be presented to both CD4⁺ and CD8⁺ T cells, making it a potential new target for immunotherapy of EBV-related cancers.

The Rockefeller University Press

2004

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