Virus infections of the lung are thought to predispose individuals to asthma, a disease characterized by eosinophil infiltration of the airways. CD8+ T cells are an important part of the host response to virus infection, however, they have no reported role in eosinophil recruitment. We developed a mouse model of virus peptide-stimulated CD8+ T cell immune responses in the lung. We found that bystander CD4+ T helper cell type 2 immune responses to ovalbumin switched the virus peptide-specific CD8+ T cells in the lung to interleukin (IL) 5 production. Furthermore, when such IL-5-producing CD8 T cells were challenged via the airways with virus peptide, a significant eosinophil infiltration was induced. In vitro studies indicated that IL-4 could switch the virus-specific CD8+ T cells to IL-5 production. These results could explain the link between virus infection and acute exacerbation of asthma and, perhaps more importantly, they indicate an IL-4-dependent mechanism that would impair CD8+ T cell responses and delay viral clearance from the host.
Brief Definitive Report|
March 01 1995
Virus-specific CD8+ cells can switch to interleukin 5 production and induce airway eosinophilia.
A J Coyle,
A J Coyle
Department of Asthma and Allergy, CIBA-GEIGY Ltd., Basel, Switzerland.
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F Erard,
F Erard
Department of Asthma and Allergy, CIBA-GEIGY Ltd., Basel, Switzerland.
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C Bertrand,
C Bertrand
Department of Asthma and Allergy, CIBA-GEIGY Ltd., Basel, Switzerland.
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S Walti,
S Walti
Department of Asthma and Allergy, CIBA-GEIGY Ltd., Basel, Switzerland.
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H Pircher,
H Pircher
Department of Asthma and Allergy, CIBA-GEIGY Ltd., Basel, Switzerland.
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G Le Gros
G Le Gros
Department of Asthma and Allergy, CIBA-GEIGY Ltd., Basel, Switzerland.
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A J Coyle
Department of Asthma and Allergy, CIBA-GEIGY Ltd., Basel, Switzerland.
F Erard
Department of Asthma and Allergy, CIBA-GEIGY Ltd., Basel, Switzerland.
C Bertrand
Department of Asthma and Allergy, CIBA-GEIGY Ltd., Basel, Switzerland.
S Walti
Department of Asthma and Allergy, CIBA-GEIGY Ltd., Basel, Switzerland.
H Pircher
Department of Asthma and Allergy, CIBA-GEIGY Ltd., Basel, Switzerland.
G Le Gros
Department of Asthma and Allergy, CIBA-GEIGY Ltd., Basel, Switzerland.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1995) 181 (3): 1229–1233.
Citation
A J Coyle, F Erard, C Bertrand, S Walti, H Pircher, G Le Gros; Virus-specific CD8+ cells can switch to interleukin 5 production and induce airway eosinophilia. . J Exp Med 1 March 1995; 181 (3): 1229–1233. doi: https://doi.org/10.1084/jem.181.3.1229
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