The tumor necrosis factor (TNF) alpha gene lies within the class III region of the major histocompatibility complex (MHC), telomeric to the class II and centromeric to the class I region. We have recently described the first polymorphism within the human TNF-alpha locus. This is biallelic and lies within the promoter region. Frequency analysis of the TNF-alpha polymorphism, using the polymerase chain reaction and single-stranded conformational polymorphism, in HLA-typed individuals, reveals a very strong association between the uncommon TNF allele and HLA A1, B8, and DR3 alleles. This is the first association between TNF-alpha and other MHC alleles and raises the possibility that the uncommon TNF-alpha allele may contribute to the many autoimmune associations of the A1,B8,DR3 haplotype.
Article|
February 01 1993
An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles.
A G Wilson
,
A G Wilson
Department of Medicine, University of Sheffield, Royal Hallamshire Hospital, UK.
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N de Vries
,
N de Vries
Department of Medicine, University of Sheffield, Royal Hallamshire Hospital, UK.
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F Pociot
,
F Pociot
Department of Medicine, University of Sheffield, Royal Hallamshire Hospital, UK.
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F S di Giovine
,
F S di Giovine
Department of Medicine, University of Sheffield, Royal Hallamshire Hospital, UK.
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L B van der Putte
,
L B van der Putte
Department of Medicine, University of Sheffield, Royal Hallamshire Hospital, UK.
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G W Duff
G W Duff
Department of Medicine, University of Sheffield, Royal Hallamshire Hospital, UK.
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A G Wilson
Department of Medicine, University of Sheffield, Royal Hallamshire Hospital, UK.
N de Vries
Department of Medicine, University of Sheffield, Royal Hallamshire Hospital, UK.
F Pociot
Department of Medicine, University of Sheffield, Royal Hallamshire Hospital, UK.
F S di Giovine
Department of Medicine, University of Sheffield, Royal Hallamshire Hospital, UK.
L B van der Putte
Department of Medicine, University of Sheffield, Royal Hallamshire Hospital, UK.
G W Duff
Department of Medicine, University of Sheffield, Royal Hallamshire Hospital, UK.
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1993) 177 (2): 557–560.
Citation
A G Wilson, N de Vries, F Pociot, F S di Giovine, L B van der Putte, G W Duff; An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles.. J Exp Med 1 February 1993; 177 (2): 557–560. doi: https://doi.org/10.1084/jem.177.2.557
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