IgA, the predominant isotype in secretions, mediates the neutralization and removal of environmental antigens from mucosal sites. Although cell surface receptors for the Fc region of IgA (Fc alpha R) have been implicated in a variety of immune effector mechanisms, the molecular features of Fc alpha R remain only marginally characterized. In this report, we describe the isolation of a clone from a myeloid cell line cDNA library that directs the expression of a cell surface molecule with IgA binding specificity. The cDNA encodes a peptide of Mr 30,000 including a putative transmembrane region with features atypical of conventional membrane-anchored proteins. Databank searches indicate that the human myeloid cell Fc alpha R sequence is unique, is a member of the immunoglobulin gene superfamily, and is related to Fc receptors for IgG (Fc gamma RI, II, and III) and IgE (Fc epsilon RI).
Article|
December 01 1990
Expression cloning of a human Fc receptor for IgA.
C R Maliszewski,
C R Maliszewski
Immunex Corporation, Seattle, Washington 98101.
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C J March,
C J March
Immunex Corporation, Seattle, Washington 98101.
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M A Schoenborn,
M A Schoenborn
Immunex Corporation, Seattle, Washington 98101.
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S Gimpel,
S Gimpel
Immunex Corporation, Seattle, Washington 98101.
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L Shen
L Shen
Immunex Corporation, Seattle, Washington 98101.
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C R Maliszewski
Immunex Corporation, Seattle, Washington 98101.
C J March
Immunex Corporation, Seattle, Washington 98101.
M A Schoenborn
Immunex Corporation, Seattle, Washington 98101.
S Gimpel
Immunex Corporation, Seattle, Washington 98101.
L Shen
Immunex Corporation, Seattle, Washington 98101.
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1990) 172 (6): 1665–1672.
Citation
C R Maliszewski, C J March, M A Schoenborn, S Gimpel, L Shen; Expression cloning of a human Fc receptor for IgA.. J Exp Med 1 December 1990; 172 (6): 1665–1672. doi: https://doi.org/10.1084/jem.172.6.1665
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