An IgM-binding protein of approximately 60 kD has been identified on activated B cells, but not on resting and activated T cells, monocytes, or granulocytes. Here, we characterize this IgM-binding protein as a receptor for the Fc portion (CH3 and/or CH4 domains) of IgM molecules (Fc microR). The Fc microR can be expressed as a cell surface activation antigen throughout the pre-B and B cell stages in differentiation. Receptor expression is not directly linked with IgM production, as both mu- pre-B cells and isotype-switched B cells may express the Fc microR. The receptor molecules produced by both pre-B and B cells are identical in size and are characterized as an acidic sialoglycoprotein with O-linked, but no N-linked, oligosaccharide. The Fc microR is anchored to the surface of B-lineage cells via a glycosyl phosphatidylinositol linkage. The Fc microR is thus the third member of a family of Fc receptors expressed on B-lineage cells, and its preferential expression on activated B cells suggests a potential role in the response to antigens.
Article|
October 01 1990
Biochemical nature of an Fc mu receptor on human B-lineage cells.
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T Ohno
,
T Ohno
Department of Medicine, University of Alabama, Birmingham 35294.
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H Kubagawa
,
H Kubagawa
Department of Medicine, University of Alabama, Birmingham 35294.
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S K Sanders
,
S K Sanders
Department of Medicine, University of Alabama, Birmingham 35294.
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M D Cooper
M D Cooper
Department of Medicine, University of Alabama, Birmingham 35294.
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T Ohno
Department of Medicine, University of Alabama, Birmingham 35294.
H Kubagawa
Department of Medicine, University of Alabama, Birmingham 35294.
S K Sanders
Department of Medicine, University of Alabama, Birmingham 35294.
M D Cooper
Department of Medicine, University of Alabama, Birmingham 35294.
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1990) 172 (4): 1165–1175.
Citation
T Ohno, H Kubagawa, S K Sanders, M D Cooper; Biochemical nature of an Fc mu receptor on human B-lineage cells.. J Exp Med 1 October 1990; 172 (4): 1165–1175. doi: https://doi.org/10.1084/jem.172.4.1165
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