In this paper we have shown that extensively purified human B lymphocytes respond to IL-4 treatment with a marked production of IL-6. Addition of anti-mu potentiated the effect of IL-4 on IL-6 production. Other cytokines tested like TNF-alpha and-beta, IFN-gamma, IL-1, IL-2, and IL-5 did not induce IL-6 secretion when given to resting B cells. Although B cells generally also produced TNF-alpha and TNF-beta upon stimulation, IL-4 did not induce TNF secretion and seemingly had a specific effect on IL-6 production.
Interleukin 4 induces selective production of interleukin 6 from normal human B lymphocytes.
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E B Smeland, H K Blomhoff, S Funderud, M R Shalaby, T Espevik; Interleukin 4 induces selective production of interleukin 6 from normal human B lymphocytes.. J Exp Med 1 October 1989; 170 (4): 1463–1468. doi: https://doi.org/10.1084/jem.170.4.1463
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