IL-5 expresses various biologic effects on several types of lymphocytes, including B cells, eosinophils, and T cells. We demonstrated that the incubation of resting splenocytes from C57BL/6 mice in murine rIL-5 enhances IL-2-mediated lymphokine-activated killer (LAK) activity against various tumor cells. IL-5 alone, however, does not induce killer activity. IL-2-mediated LAK activity increases in proportion to the dose of IL-5. During the late phase of the culture period, IL-5 seems to have some effect on the induction of IL-2-mediated LAK activity. We expect that IL-5 will prove useful for adoptive immunotherapy.
Interleukin 5 enhances interleukin 2-mediated lymphokine-activated killer activity.
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T Aoki, H Kikuchi, S Miyatake, Y Oda, K Iwasaki, T Yamasaki, T Kinashi, T Honjo; Interleukin 5 enhances interleukin 2-mediated lymphokine-activated killer activity.. J Exp Med 1 August 1989; 170 (2): 583–588. doi: https://doi.org/10.1084/jem.170.2.583
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