Injection of rabbits with a human T cell line infected with HIV-1 caused seroconversion within 6 wk, and HIV-1 could be isolated from PBL cultures of infected rabbits. Identity of the isolated virus with HIV-1 was shown by analysis of products amplified by the polymerase chain reaction. HIV-1 infection was seen in rabbits injected with HIV-1-infected cells alone as well as in those that were first infected with HTLV-1 and subsequently with HIV-1. There were no consistent signs of disease in the rabbits infected with HIV-1 alone but HTLV-1/HIV-1-infected rabbits showed signs of illness including diarrhea and weight loss, transient neurologic impairment and, in one animal, a rapidly progressing mammary adenocarcinoma. Examination of organs taken at necropsy from both HIV-1- and HTLV-1/HIV-1-infected animals showed splenic hyperplasia and lymphocyte infiltration of the lungs, as well as moderate damage to liver and kidney in some cases.
Infection of rabbits with human immunodeficiency virus 1. A small animal model for acquired immunodeficiency syndrome.
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H Kulaga, T Folks, R Rutledge, M E Truckenmiller, E Gugel, T J Kindt; Infection of rabbits with human immunodeficiency virus 1. A small animal model for acquired immunodeficiency syndrome.. J Exp Med 1 January 1989; 169 (1): 321–326. doi: https://doi.org/10.1084/jem.169.1.321
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