The CD3+, IL-2-dependent normal human thymocyte clone, CII, expresses on its surface a CD3-associated gamma/delta TCR. We have further elucidated the structure of this receptor from the nucleotide sequence of cDNA and genomic clones from CII that encode functional TCR-gamma and -delta chains. We find that the CII line expresses a C gamma 2 constant region that is a polymorphic form lacking a copy of an internal exon; the sequence of this constant region accounts for the size of the gamma chain and noncovalent linkage of gamma and delta chains in the CII TCR. The V gamma region used for the CII TCR is identical to the several previously characterized expressed human V gamma segments. Possible implications of this finding are discussed.
Structure of the gamma/delta T cell receptor of a human thymocyte clone.
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A Okada, I Bank, L Rogozinski, Y Takihara, T W Mak, L Chess, F W Alt; Structure of the gamma/delta T cell receptor of a human thymocyte clone.. J Exp Med 1 October 1988; 168 (4): 1481–1486. doi: https://doi.org/10.1084/jem.168.4.1481
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