The XLR gene family consists of approximately 10 X-linked genes, the expression of which is regulated in lymphocyte development. Certain members of the gene family are closely linked to the murine xid immune deficiency mutation. Sequence analysis of a cDNA clone pM1 derived from the plasmacytoma MOPC167 showed an open reading frame capable of coding for a protein of 208 amino acids and mol wt 24,000. The lack of a signal peptide or transmembrane region indicates a probable cytoplasmic or nuclear localization for the predicted pM1 protein. The predicted protein shares significant homology with lamins A and C and other members of the intermediate filament family of proteins, and shares features important for the coiled-coil structure proposed for these proteins. Analysis of cDNA clones derived from a presecretory lymphoma and from adult thymus indicates that B and T lymphocytes transcribe a common major mRNA identical to pM1, while other rare transcripts were also identified by these studies. A series of clonal T lymphoma lines representing distinct stages of thymic differentiation showed that, as with B lymphoid tumors, XLR expression is correlated with the maturation of the thymomas.
Sequence analysis and expression of an X-linked, lymphocyte-regulated gene family (XLR).
- Views Icon Views
- PDF LinkPDF
- Share Icon Share
- Search Site
J N Siegel, C A Turner, D M Klinman, M Wilkinson, A D Steinberg, C L MacLeod, W E Paul, M M Davis, D I Cohen; Sequence analysis and expression of an X-linked, lymphocyte-regulated gene family (XLR).. J Exp Med 1 December 1987; 166 (6): 1702–1715. doi: https://doi.org/10.1084/jem.166.6.1702
Download citation file: