We have presented data showing that IFN-beta at 1,000 U/mouse i.v. inhibits the generation of Ts-mediated tolerance to dinitrofluorobenzene (DNFB) and abrogates the transfer of suppression by Ts. We have also presented data showing that IFN-beta up to 10,000 U/mouse i.v. has no adverse effect on sensitization and elicitation. IFN-beta appears to be a suitable agent for evaluation as an adjunct in the immunotherapy of Ts inducing tumors.
Article| November 01 1987
Inhibition of suppressor T lymphocytes by murine interferon beta.
D M Sahasrabudhe
Cancer Center, University of Rochester School of Medicine and Dentistry, New York 14642.
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1987) 166 (5): 1573–1578.
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D M Sahasrabudhe; Inhibition of suppressor T lymphocytes by murine interferon beta.. J Exp Med 1 November 1987; 166 (5): 1573–1578. doi: https://doi.org/10.1084/jem.166.5.1573
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