This is the first report demonstrating that C3d receptor (CR2) has functional activity in regulating complement cascade. Purified CR2 was examined for its cofactor activity in factor I-mediated cleavage of membrane-bound iC3b. CR2 plus C3b inactivator (I) released C3c from EA 125I-iC3b, and the release was inhibited when CR2 was preincubated with OKB7 monoclonal anti-CR2. Furthermore, immunoelectroblotting analysis showed crossreactivity of CR2 with 57H anti-CR1. These results indicate that CR2 has functional and antigenic similarity to CR1, thus providing a supporting evidence for placement of CR2 as a member of the recently defined gene family of C3- and C4-regulatory proteins composed of CR1, C4-binding protein, and factor H.
Article| May 01 1987
Functional and antigenic properties of complement receptor type 2, CR2.
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1987) 165 (5): 1424–1429.
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K Mitomo, T Fujita, K Iida; Functional and antigenic properties of complement receptor type 2, CR2.. J Exp Med 1 May 1987; 165 (5): 1424–1429. doi: https://doi.org/10.1084/jem.165.5.1424
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