Three new human lambda L chain-like Ig genes are identified by restriction enzyme and nucleotide sequence analysis. Two genes, 14.1 and 16.1, have intact J and C regions, and are potentially functional, with open reading frames. A third gene, 18.1, is a pseudogene. The evolutionary lineage of these genes compared to the known functional locus lambda C1-lambda C6 can be surmised from Southern blot and nucleotide homologies. This study demonstrates that the human lambda gene family is more complex than previously recognized.
Identification of three new Ig lambda-like genes in man.
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H Chang, E Dmitrovsky, P A Hieter, K Mitchell, P Leder, L Turoczi, I R Kirsch, G F Hollis; Identification of three new Ig lambda-like genes in man.. J Exp Med 1 February 1986; 163 (2): 425–435. doi: https://doi.org/10.1084/jem.163.2.425
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