Radiation chimeras were made by restoring lethally irradiated inbred mice with bone marrow cells of F1 hybrid mice of crosses between that inbred strain and an H-2-congenic strain. The urine of these chimeras was tested by the Y maze method, and shown to have acquired a scent indicative of the reconstituting donors' H-2 type. Thus, cells of the hematopoietic system contribute to the H-2-related odorant properties that enable mice to distinguish one another according to their H-2 types.
The hematopoietic system is a source of odorants that distinguish major histocompatibility types.
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K Yamazaki, G K Beauchamp, L Thomas, E A Boyse; The hematopoietic system is a source of odorants that distinguish major histocompatibility types.. J Exp Med 1 October 1985; 162 (4): 1377–1380. doi: https://doi.org/10.1084/jem.162.4.1377
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