Replication of measles virus was restricted in human peripheral blood mononuclear cells (PBMC). However, in in vitro-infected, unstimulated cells, active synthesis of viral RNA and proteins occurred, while the release of infectious virus could not be detected. Stimulation with PHA caused a productive infection cycle comparable to the lytic infection. Replication of viral RNA was demonstrated in both T and B cells, and in both OKT4+- and OKT8+-depleted T cell subsets. The presence of measles virus RNA was detected in PBMC isolated from measles patients, and the production of the immunoreactive hemagglutinin protein was defective in these cells.
Article| June 01 1985
Replication of measles virus in human lymphocytes.
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1985) 161 (6): 1261–1271.
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T Hyypiä, P Korkiamäki, R Vainionpää; Replication of measles virus in human lymphocytes.. J Exp Med 1 June 1985; 161 (6): 1261–1271. doi: https://doi.org/10.1084/jem.161.6.1261
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