A complete set of a rearranged human gamma 1-heavy chain gene, HIG1, was cloned from human plasma cell leukemia line, ARH-77, and transferred into mouse cells. It was strongly expressed in mouse myeloma cells but not in mouse L cells, indicating that immunoglobulin gene expression is not species-specific but cell-specific. However, a remarkable production of human gamma 1 chain was induced in mouse L cells containing HIG1 gene when the cells were treated with cycloheximide for a short period. The role of a labile repressor molecule in the expression of the immunoglobulin gene is proposed.
Article| December 01 1984
Induction of immunoglobulin gene expression in mouse fibroblasts by cycloheximide treatment.
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1984) 160 (6): 1937–1942.
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T Ishihara, A Kudo, T Watanabe; Induction of immunoglobulin gene expression in mouse fibroblasts by cycloheximide treatment.. J Exp Med 1 December 1984; 160 (6): 1937–1942. doi: https://doi.org/10.1084/jem.160.6.1937
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