Hookworms of the genus Ancylostoma secrete an anticoagulant that both inhibits the clotting of human plasma and promotes fibrin clot dissolution. This anticoagulant activity is attributable to a 36,000 dalton proteolytic enzyme. The protease can degrade fibrinogen into five smaller polypeptides that intrinsically have anticoagulating properties, covert plasminogen to a mini-plasminogen-like molecule, and hydrolyze a synthetic peptide substrate with specificity for elastolytic enzymes. It is hypothesized that the parasite uses this enzyme to prevent blood clotting while feeding on villous capillaries.
Article| May 01 1983
Secretion of a proteolytic anticoagulant by Ancylostoma hookworms.
P J Hotez
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1983) 157 (5): 1594–1603.
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P J Hotez, A Cerami; Secretion of a proteolytic anticoagulant by Ancylostoma hookworms.. J Exp Med 1 May 1983; 157 (5): 1594–1603. doi: https://doi.org/10.1084/jem.157.5.1594
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