Cell-cell interactions between mature T cells and peripheral blood null cells induce erythropoietin-stimulated differentiation of peripheral blood-derived erythroid progenitors. By the use of complement-fixing cytolytic murine hybridoma and antibody uniquely reactive with mature T lymphocytes, this dependence of immature peripheral blood erythroid burst-forming unit (BFU-E) differentiation upon mature T cells or a T cell conditioned medium is confirmed. By using the same antibody, it is demonstrated that the differentiation of mature bone marrow BFU-E does not require either mature T cells or lymphocyte mitogenic factor. These findings do not preclude the presence in the bone marrow of other cells, perhaps even immature T cells, that influence erythropoietin-dependent erythroid differentiation of mature marrow BFU-E.
Mature bone marrow erythroid burst-forming units do not require T cells for induction of erythropoietin-dependent differentiation.
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J M Lipton, E L Reinherz, M Kudisch, P L Jackson, S F Schlossman, D G Nathan; Mature bone marrow erythroid burst-forming units do not require T cells for induction of erythropoietin-dependent differentiation.. J Exp Med 1 August 1980; 152 (2): 350–360. doi: https://doi.org/10.1084/jem.152.2.350
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