We have determined the Ly phenotype of the T lymphocytes which proliferate in response to mutant H-2K and H-2D alloantigens in primary mixed lymphocyte culture. Responder T cells proliferating in reciprocal cultures of H-2d(KdDd) and H-2da(KdDda) lymphocytes were typed Ly 2+ through selective depletion with specific alloantiserum plus complement. Further, B6-Ly 1a lymphocytes proliferating in response to B6-H-2ba and B6-H-2bf stimulators were typed as Ly 1+2+ through similar analysis. These results are discussed with regard to their impact on views of lymphocyte differentiation and factors determining the identity of alloreactive lymphocytes.
T-lymphocyte response to H-2 mutants. I. Proliferation is dependent on Ly 1+2+ cells.
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P J Wettstein, D W Bailey, L E Mobraaten, J Klein, J A Frelinger; T-lymphocyte response to H-2 mutants. I. Proliferation is dependent on Ly 1+2+ cells.. J Exp Med 1 May 1978; 147 (5): 1395–1404. doi: https://doi.org/10.1084/jem.147.5.1395
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