The HLA and Bf genotypes were determined in 10 families with one or more children with JDM. A statistically significant association was found between HLA-D-identity and the chance to present JDM within a sibship. No such association was detectable with the SD antigens. A highly significant increase in the frequency of intra-HLA recombination was also found in these families.
The HLA system in the families of patients with juvenile diabetes mellitus.
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P Rubinstein, N Suciu-Foca, J F Nicholson, M Fotino, A Molinaro, L Harisiadis, M A Hardy, K Reemtsma, F H Allen; The HLA system in the families of patients with juvenile diabetes mellitus.. J Exp Med 1 May 1976; 143 (5): 1277–1282. doi: https://doi.org/10.1084/jem.143.5.1277
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