While spleen cells from neonatal B10 (H-2b) are reactive (proliferate) in one-way mixed leukocyte culture, cell-mediated lympholysis reactivity does not arise until 7 days of age. When B10 cells are sensitized to B10.D2 (H-2d), cross-killing of third-party B10.BR (H-2k) target is always lower than the specific killing of B10.D2 targets and is not demonstrable until 27 days after birth.
Cell-mediated immunity: differential maturation of mixed leukocyte reaction and cell-mediated lympholysis.
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S Wu, F H Bach, R Auerbach; Cell-mediated immunity: differential maturation of mixed leukocyte reaction and cell-mediated lympholysis. . J Exp Med 1 November 1975; 142 (5): 1301–1305. doi: https://doi.org/10.1084/jem.142.5.1301
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