Serum from CBA/J mice made amyloidotic by chronic casein injections has been shown to suppress in vitro antibody response to SRBC. Similar suppression was also found with normal mouse serum but to a much lesser degree. This suppressive activity of both amyloidotic serum and normal serum was removed by absorption of the sera with antiserum to protein AA, the major constituent of casein-induced (secondary) amyloid fibrils. This antiserum to the amyloid fibril protein AA (mol wt 8,400 daltons) detects an immunologically cross-reacting serum alpha globulin (SAA) (mol wt approx. 100,000). It is postulated that the serum factor (SAA) is a regulator of antibody response and may be present in elevated amounts as the result of chronic antigenic stimulation.
Suppression of in vitro antibody response by a serum factor (SAA) in experimentally induced amyloidosis.
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M D Benson, M A Aldo-Benson, T Shirahama, Y Borel, A S Cohen; Suppression of in vitro antibody response by a serum factor (SAA) in experimentally induced amyloidosis.. J Exp Med 1 July 1975; 142 (1): 236–241. doi: https://doi.org/10.1084/jem.142.1.236
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