During blood coagulation ultrastructural lesions were produced on the platelet membrane. They were dependent on the presence of both thrombin and complement (C) and were morphologically identical to the C-dependent ultrastructural lesions (type II) seen in red cells subsequent to activation of C by the alternate mechanismmthough similar in shape they differed in size from ultrastructural lesions (type I) PRODUCED BY ACTIVATION OF C via the classic mechanismmlesions of type I were seen on the platelet surface subsequent to antibody-dependent activation of the C system.
Ultrastructural lesions on the surface of platelets associated with either blood coagulation or with antibody-mediated immune injury.
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M J Polley, R L Nachman; Ultrastructural lesions on the surface of platelets associated with either blood coagulation or with antibody-mediated immune injury.. J Exp Med 1 June 1975; 141 (6): 1261–1268. doi: https://doi.org/10.1084/jem.141.6.1261
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