AKR/J (H-2kk) mice have higher serum C3 levels than DBA/2J (H-2dd). The F1 hybrids have intermediate levels. Analysis of the progeny of backcrosses at 21 days of age shows that C3 levels in mice of H-2dk type are significantly higher than those with H-2dd type and lower than those with H-2kk type. In addition, mice of H-2kk, H-2dk, and H-2dd types have C3 levels not significantly different from those of AKR/J, AKD2F1, and DBA/2J respectively. These findings demonstrate linkage between a gene controlling C3 levels and the H-2 complex.
Article| February 01 1975
Genetic linkage between serum levels of the third component of complement and the H-2 complex.
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1975) 141 (2): 513–517.
- Views Icon Views
- PDF LinkPDF
- Share Icon Share
- Search Site
A Ferreira, V Nussenzweig; Genetic linkage between serum levels of the third component of complement and the H-2 complex.. J Exp Med 1 February 1975; 141 (2): 513–517. doi: https://doi.org/10.1084/jem.141.2.513
Download citation file: