Five adjuvant induced BALB/c tumors producing IgM—McPc 1748, W 3469, TEPC 183, McPc 774, and Y 5781—were characterized morphologically by electron microscopy, analysis of the distribution of surface-bound and intracytoplasmic IgM using immunofluorescence, and by biochemical study of IgM synthesis, turnover, and secretion. The cells of different tumors appear to represent different stages in B-cell maturation when compared to normal, lipopolysaccharide-stimulated B cells. Thus, McPc 1748 tumor cells resemble 10–25-h stimulated normal B cells, 3469 cells resemble 20–35-h stimulated B cells, TEPC 183 cells resemble 45–65-h stimulated B cells, Y 5781 cells resemble 80–110-h stimulated B cells, and McPc 774 cells resemble 100–130-h stimulated B cells.
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1 September 1974
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September 01 1974
IgM-PRODUCING TUMORS IN THE BALB/c MOUSE : A MODEL FOR B-CELL MATURATION
Jan Andersson,
Jan Andersson
From the Basel Institute for Immunology, CH- 4058 Basel, Switzerland, the Manhattan Veterans Administration Hospital, New York, 10010, and the Mt. Sinai School of Medicine, New York, 10029
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Joel Buxbaum,
Joel Buxbaum
From the Basel Institute for Immunology, CH- 4058 Basel, Switzerland, the Manhattan Veterans Administration Hospital, New York, 10010, and the Mt. Sinai School of Medicine, New York, 10029
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Ronald Citronbaum,
Ronald Citronbaum
From the Basel Institute for Immunology, CH- 4058 Basel, Switzerland, the Manhattan Veterans Administration Hospital, New York, 10010, and the Mt. Sinai School of Medicine, New York, 10029
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Steven Douglas,
Steven Douglas
From the Basel Institute for Immunology, CH- 4058 Basel, Switzerland, the Manhattan Veterans Administration Hospital, New York, 10010, and the Mt. Sinai School of Medicine, New York, 10029
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Luciana Forni,
Luciana Forni
From the Basel Institute for Immunology, CH- 4058 Basel, Switzerland, the Manhattan Veterans Administration Hospital, New York, 10010, and the Mt. Sinai School of Medicine, New York, 10029
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Fritz Melchers,
Fritz Melchers
From the Basel Institute for Immunology, CH- 4058 Basel, Switzerland, the Manhattan Veterans Administration Hospital, New York, 10010, and the Mt. Sinai School of Medicine, New York, 10029
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Benvenuto Pernis,
Benvenuto Pernis
From the Basel Institute for Immunology, CH- 4058 Basel, Switzerland, the Manhattan Veterans Administration Hospital, New York, 10010, and the Mt. Sinai School of Medicine, New York, 10029
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David Stott
David Stott
From the Basel Institute for Immunology, CH- 4058 Basel, Switzerland, the Manhattan Veterans Administration Hospital, New York, 10010, and the Mt. Sinai School of Medicine, New York, 10029
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Jan Andersson
From the Basel Institute for Immunology, CH- 4058 Basel, Switzerland, the Manhattan Veterans Administration Hospital, New York, 10010, and the Mt. Sinai School of Medicine, New York, 10029
Joel Buxbaum
From the Basel Institute for Immunology, CH- 4058 Basel, Switzerland, the Manhattan Veterans Administration Hospital, New York, 10010, and the Mt. Sinai School of Medicine, New York, 10029
Ronald Citronbaum
From the Basel Institute for Immunology, CH- 4058 Basel, Switzerland, the Manhattan Veterans Administration Hospital, New York, 10010, and the Mt. Sinai School of Medicine, New York, 10029
Steven Douglas
From the Basel Institute for Immunology, CH- 4058 Basel, Switzerland, the Manhattan Veterans Administration Hospital, New York, 10010, and the Mt. Sinai School of Medicine, New York, 10029
Luciana Forni
From the Basel Institute for Immunology, CH- 4058 Basel, Switzerland, the Manhattan Veterans Administration Hospital, New York, 10010, and the Mt. Sinai School of Medicine, New York, 10029
Fritz Melchers
From the Basel Institute for Immunology, CH- 4058 Basel, Switzerland, the Manhattan Veterans Administration Hospital, New York, 10010, and the Mt. Sinai School of Medicine, New York, 10029
Benvenuto Pernis
From the Basel Institute for Immunology, CH- 4058 Basel, Switzerland, the Manhattan Veterans Administration Hospital, New York, 10010, and the Mt. Sinai School of Medicine, New York, 10029
David Stott
From the Basel Institute for Immunology, CH- 4058 Basel, Switzerland, the Manhattan Veterans Administration Hospital, New York, 10010, and the Mt. Sinai School of Medicine, New York, 10029
Received:
May 30 1974
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1974 by The Rockefeller University Press
1974
J Exp Med (1974) 140 (3): 742–763.
Article history
Received:
May 30 1974
Connected Content
This article has been corrected
IgM-PRODUCING TUMORS IN THE BALB/c MOUSE : A MODEL FOR B-CELL MATURATION
Citation
Jan Andersson, Joel Buxbaum, Ronald Citronbaum, Steven Douglas, Luciana Forni, Fritz Melchers, Benvenuto Pernis, David Stott; IgM-PRODUCING TUMORS IN THE BALB/c MOUSE : A MODEL FOR B-CELL MATURATION . J Exp Med 1 September 1974; 140 (3): 742–763. doi: https://doi.org/10.1084/jem.140.3.742
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