Interaction of polyoma virus, specific antibody, and complement has been studied. Firm evidence has been gathered that C1 through C3 and not C5 through C9 enhance neutralization of virus-antiviral antibody (V-Ab) complexes. C enhancement of neutralization occurs primarily by agglutination of V-Ab complexes and not by virion lysis or attachment of large protein molecules to the V-Ab complex. In this model, binding of C1, 4, 2, 3 to the V-Ab complex may explain why some viruses concentrate in or infect certain cells bearing C3 receptors such as B lymphocytes, macrophages, and monocytes.
FORMATION AND BIOLOGIC ROLE OF POLYOMA VIRUS-ANTIBODY COMPLEXES : A CRITICAL ROLE FOR COMPLEMENT
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Michael B. A. Oldstone, Neil R. Cooper, David L. Larson; FORMATION AND BIOLOGIC ROLE OF POLYOMA VIRUS-ANTIBODY COMPLEXES : A CRITICAL ROLE FOR COMPLEMENT . J Exp Med 1 August 1974; 140 (2): 549–565. doi: https://doi.org/10.1084/jem.140.2.549
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