The present studies were undertaken to analyze the nature of the effect of bacterial lipopolysaccharide (LPS) on antibody production in vitro. We have done this by making comparative studies of the effects of LPS on in vitro primary and secondary antibody responses to soluble hapten-protein conjugates and to particulate and soluble sheep erythrocyte antigens. The results obtained demonstrate that the biological action of LPS in vitro may be predominantly manifested on the function of B lymphocytes or T lymphocytes depending on the conditions employed. In the absence of antigen, LPS appears to act primarily on B lymphocytes. In the presence of antigen, however, the data presented here show that LPS significantly influences specific helper T-cell function and it is this latter influence that is predominantly responsible for the adjuvant effects of LPS on antigen-specific antibody responses.
Article|
January 01 1974
ACTIVATION OF T AND B LYMPHOCYTES IN VITRO : I. REGULATORY INFLUENCE OF BACTERIAL LIPOPOLYSACCHARIDE (LPS) ON SPECIFIC T-CELL HELPER FUNCTION
Dieter Armerding,
Dieter Armerding
From the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115
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David H. Katz
David H. Katz
From the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115
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Dieter Armerding
From the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115
David H. Katz
From the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115
Received:
September 20 1973
Online Issn: 1540-9538
Print Issn: 0022-1007
Copyright © 1974 by The Rockefeller University Press
1974
J Exp Med (1974) 139 (1): 24–43.
Article history
Received:
September 20 1973
Citation
Dieter Armerding, David H. Katz; ACTIVATION OF T AND B LYMPHOCYTES IN VITRO : I. REGULATORY INFLUENCE OF BACTERIAL LIPOPOLYSACCHARIDE (LPS) ON SPECIFIC T-CELL HELPER FUNCTION . J Exp Med 1 January 1974; 139 (1): 24–43. doi: https://doi.org/10.1084/jem.139.1.24
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