CELL-TO-CELL INTERACTION IN THE IMMUNE RESPONSE VIII. RADIOSENSITIVITY OF THYMUS-DERIVED LYMPHOCYTES

Anderson , R. E.; Sprent , J.; Miller , J. F. A. P.

doi:10.1084/jem.135.3.711

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Brief Definitive Report| March 01 1972

CELL-TO-CELL INTERACTION IN THE IMMUNE RESPONSE : VIII. RADIOSENSITIVITY OF THYMUS-DERIVED LYMPHOCYTES

In Special Collection: 2019 Lasker Prize Collection

R. E. Anderson,

R. E. Anderson

From the Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia

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J. Sprent,

J. Sprent

From the Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia

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J. F. A. P. Miller

From the Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia

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Author and Article Information

R. E. Anderson

From the Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia

J. Sprent

From the Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia

J. F. A. P. Miller

From the Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia

Received: January 04 1972

Online ISSN: 1540-9538

Print ISSN: 0022-1007

1972

J Exp Med (1972) 135 (3): 711–717.

https://doi.org/10.1084/jem.135.3.711

The helper function of carrier-primed T cells was found to be radiosensitive in vivo. The results could not be attributed to interference with the spleen-seeking properties of the irradiated cells. It is suggested that T cell division is essential for the induction of 7S antibody responses in vivo.

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