Evidence for the involvement of the sixth component of complement (C6) in normal blood coagulation is provided by the description of a coagulation abnormality in rabbits with a genetic C6 deficiency and by its correction with highly purified preparations of C6. Whole blood clotting time in glass or plastic was prolonged and prothrombin consumption was decreased in blood from the deficient animals. Other parameters of blood coagulation were normal, including prothrombin time, partial thromboplastin time, specific clotting factor activities, platelet factor III function, platelet count, and bleeding time. Clotting time and prothrombin consumption became normal when physiologic amounts of highly purified C6 were added to the deficient blood. Partial consumption of C6 hemolytic activity, with a time course similar to the consumption of prothrombin, was demonstrated during the clotting of normal human blood.
Article|
December 01 1971
A BLOOD COAGULATION ABNORMALITY IN RABBITS DEFICIENT IN THE SIXTH COMPONENT OF COMPLEMENT (C6) AND ITS CORRECTION BY PURIFIED C6
Theodore S. Zimmerman,
Theodore S. Zimmerman
From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037
Search for other works by this author on:
Carlos M. Arroyave,
Carlos M. Arroyave
From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037
Search for other works by this author on:
Hans J. Müller-Eberhard
Hans J. Müller-Eberhard
From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037
Search for other works by this author on:
Theodore S. Zimmerman
From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037
Carlos M. Arroyave
From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037
Hans J. Müller-Eberhard
From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037
Received:
August 16 1971
Online Issn: 1540-9538
Print Issn: 0022-1007
Copyright © 1971 by The Rockefeller University Press
1971
J Exp Med (1971) 134 (6): 1591–1600.
Article history
Received:
August 16 1971
Citation
Theodore S. Zimmerman, Carlos M. Arroyave, Hans J. Müller-Eberhard; A BLOOD COAGULATION ABNORMALITY IN RABBITS DEFICIENT IN THE SIXTH COMPONENT OF COMPLEMENT (C6) AND ITS CORRECTION BY PURIFIED C6 . J Exp Med 1 December 1971; 134 (6): 1591–1600. doi: https://doi.org/10.1084/jem.134.6.1591
Download citation file: