The studies reported here demonstrate that immunocompetent lymphoid cells from allogeneic donor guinea pigs stimulate the synthesis of anti-DNP and anti-OVA antibodies by recipients previously primed with DNP-OVA. This allogeneic effect occurs spontaneously in the absence of any further anti-genic challenge. Furthermore, the transfer of allogeneic cells prepares DNP-OVA-primed recipients for a striking secondary anti-DNP response to DNP-BGG; this occurs in equal degree whether or not the cells are derived from BGG-primed donors. We suggest that the allogeneic cells function by virtue of a specific immunologic attack of grafted cells on host cells. This conclusion is made on the basis of the following evidence: (a) The failure of observing the phenomenon with L2C leukemia cells and irradiated strain 2 lymph node and spleen cells which, although capable of initiating a host-versus-graft response, are incapable of mediating graft-versus-host reactions; and (b) the inability of (strain 2 x strain 13) F1 hybrids to mediate the allogeneic effect in strain 13 recipients. The analysis of this phenomenon may offer a key to the delineation of mechanisms involved in the activation of precursors of antibody-forming cells.
CARRIER FUNCTION IN ANTI-HAPTEN ANTIBODY RESPONSES : III. STIMULATION OF ANTIBODY SYNTHESIS AND FACILITATION OF HAPTEN-SPECIFIC SECONDARY ANTIBODY RESPONSES BY GRAFT-VERSUS-HOST REACTIONS
- Views Icon Views
- PDF LinkPDF
- Share Icon Share
- Search Site
David H. Katz, William E. Paul, Edmond A. Goidl, Baruj Benacerraf; CARRIER FUNCTION IN ANTI-HAPTEN ANTIBODY RESPONSES : III. STIMULATION OF ANTIBODY SYNTHESIS AND FACILITATION OF HAPTEN-SPECIFIC SECONDARY ANTIBODY RESPONSES BY GRAFT-VERSUS-HOST REACTIONS . J Exp Med 1 February 1971; 133 (2): 169–186. doi: https://doi.org/10.1084/jem.133.2.169
Download citation file: